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Recommendations for trace amine receptor nomenclature"". The dysregulation of TA levels has been linked to several diseases, which highlights the corresponding members of the TAAR family as potential targets for drug development.
In this article, we focus on the relevance of TAs and their receptors to nervous system-related disorders, namely schizophrenia and depression; however, TAs have also been linked to other diseases such as migraine, attention deficit hyperactivity disorder, substance abuse and eating disorders [7,8,36].
Although the functional role of trace amines in mammals remains largely enigmatic, it has been noted that trace amine levels can be altered in various human disorders, including schizophrenia, Parkinson's disease, attention deficit hyperactivity disorder ADHDTourette syndrome, and phenylketonuria Boulton, ; Sandler et al. It was dating hindi song held that trace amines affect the monoamine system indirectly via interaction with plasma membrane transporters [such as plasma membrane dopamine transporter DAT ] and vesicular storage Premont et al.
Furthermore, DAT-deficient mice provide a model to investigate the inhibitory actions of amphetamines on hyperactivity, the feature of amphetamines believed to be important for their therapeutic action in ADHD Gainetdinov et al. Rev Recent Clin Trials. PE has been shown to induce hyperactivity and aggression, two of the cardinal clinical features of ADHD, in experimental animals .
Hyperactivity is also a symptom of phenylketonuria, which as discussed above is associated with a markedly elevated PE turnover .
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